In this seminar, Assistant Professor of Neurology Hugo Aparicio, MD, MPH, covers a broad overview of observational studies and population-based studies as a rich source of high-quality data for answering scientific questions about neurologic disease. As a Framingham Heart Study investigator and a leading researcher in stroke, Dr. Aparicio discusses how these studies are leveraged to produce high-impact learnings for the field, and how someone who is interested in this type of research can get started working with epidemiologic datasets and seek career development and grant support for this type of endeavor.